Molecular Biology of Spermatogenesis: Novel Targets of Apparently Idiopathic Male Infertility

Epigenetics, spermatogenesis and male infertility.

Epigenetic modifications characterized by DNA methylation, histone modifications, and chromatin remodeling are important regulators in a number of biological processes, including spermatogenesis. Several genes in the testes are regulated through epigenetic mechanisms, indicating a direct influence of epigenetic mechanisms on the process of spermatogenesis. In the present article, we have provid...

The role of Musashi protein in spermatogenesis and male infertility

Background: Inactivation of transcription occurs during two phases of spermatogenesis. First, in spermatocytes entering the primary meiosis and the second in round and elongating spermatids. These stages of inactivated transcription demand extensive regulation of translation. Therefore, presence of the control on gene expression during spermatogenesis seems essential. In the cases that post-tra...

Idiopathic Male Infertility

Idiopathic Male Infertility

Idiopathic Male Infertility